The Position

The Technician CLD supports the development of processes and/or the analysis for the manufacturing of recombinant proteins with CHO cultures by executing experiments, preparing materials, and collecting data.

Your Responsibilities

• Conduct experiments and apply standard laboratory practices under moderate guidance and supervision within scope and timelines
• Document executed work in accordance to internal guidelines
• Support troubleshooting activities in collaboration with Subject Matter Expert
• Document batch results with a critical mind
• Write protocols, SOPs, using available templates
• Drive simple initiatives (in relation to job duties) with limited guidance and supervision within your team/group
• Support technology transfer activities if needed
• Follow all EHS procedures and laboratory safety standards, maintain a clean and safe workspace, and promptly report any unsafe conditions, incidents, or near misses

Job Requirements

Cell Line Development (CLD) technical skills:

• Gene synthesis, vector cloning, plasmid purification, sequencing, agarose gel electrophoresis
• Plasmid design software (e.g., vector mapping and annotation tools)
• Transfection techniques and clone selection workflows; Clonality assessment (e.g. FACSAria, FACSLyric, Single cell printing (VIPS), Cellmetric)
• Expansion and cryopreservation of cell lines
• Small-scale bioreactor systems used in early screening (e.g., Ambr15, Breez)
• E.coli culture, CHO cell suspension culture

Other desirable technical skills: Cell culture expansion in shake flasks, wave bags, and benchtop bioreactors, use of single-use bioreactors at laboratory and pilot scale, Monitoring and control of critical culture parameters (e.g., pH, DO, temperature, agitation, feeding), Routine sampling for cell growth and metabolic profiling, Basic troubleshooting and maintenance of bioreactor and support systems

• Excellent communication skills (English required, German is a plus)
• Solution-oriented mindset
• Ability to work in a fast paced environment
• Collaborative team player
• Ability to deal with changes and quickly adjust to new situations

Why Celonic?

• Make a difference by directly impacting patients lives
• Biologics is an attractive, high growth sector with professional development
• Offers a multinational and diverse workplace
• Proud to be a pioneer in “Next Generation” manufacturing technologies
• Family owned: Entrepreneurial, and short communication lines
• Basel is a great place to live, play and work in the center of Europe

About us

Celonic is a “Pure Play” Biologics Contract Development Manufacturing Organization (CDMO). Celonic’s mission is to help its customers, primarily small to large Biotech Companies, bring life-saving and improving drugs effectively to the market using innovative, “next generation” bioprocessing technologies such as, process intensification and full-perfusion. Celonic has a state-of-the-art Development and Innovation Center in Basel, Switzerland (headquarters), and clinical and commercial GMP manufacturing facilities in Heidelberg, Germany. At present, more than 500 highly qualified employees work at Celonic. Due to the expansion of the company, Celonic is looking for committed and qualified employees.

Our job is to make a difference!

http://www.celonic.com/